First of all, vitamin and mineral supplements are man-made.
Making of these supplement goes through the process of extracting and fractionating elements.
Once removed and isolated, the vitamin loses its value.
Grains of wheat taken from the tombs that are thousands or hundreds of years old would prout when placed on the ground.
This important ingredient is absence in synthesized wheat: life force.
The same ingredient is also missing in synthesized minerals and vitamins.
Dr Robert McCarter and Dr Elizabeth (1984) found that vitamin supplement becomes toxic in the body. It means the body has to work hard to remove the toxic waste.
Source of information: Diamond, H. & Diamond, M. (1985). Fit for Life. New York: Warner Books.